The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Apr. 04, 2005
Frans Eduard Janssens, Bonheide, BE;
Bruno Schoentjes, Bois-Guillaume, FR;
Sophie Coupa, Louviers, FR;
Alain Philippe Poncelet, Le Manoir sur Seine, FR;
Yvan René Ferdinand Simonnet, Rouen, FR;
Frans Eduard Janssens, Bonheide, BE;
Bruno Schoentjes, Bois-Guillaume, FR;
Sophie Coupa, Louviers, FR;
Alain Philippe Poncelet, Le Manoir sur Seine, FR;
Yvan René Ferdinand Simonnet, Rouen, FR;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NKantagonistic activity, a combined NK/NKantagonistic activity, a combined NK/NKantagonistic activity and a combined NK/NK/NKantagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, COPD and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim