The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Oct. 02, 2003
Kirsten Ebbehøj, Nærum, DK;
Trine Jepsen, Copenhagen, DK;
Carsten Boye Knudsen, Greve, DK;
Bjarne Due Larsen, Roskilde, DK;
David Knott, Hertford, DK;
Kirsten Ebbehøj, Nærum, DK;
Trine Jepsen, Copenhagen, DK;
Carsten Boye Knudsen, Greve, DK;
Bjarne Due Larsen, Roskilde, DK;
David Knott, Hertford, DK;
Zealand Pharma A/S, Glostrup, DK;
Abstract
The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, or isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds, such as for the treatment of diabetes.