The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Jan. 20, 2004
Yukun Sun, Shanghai, CN;
Dengxi Wu, Shanghai, CN;
Aizhen Wu, Shanghai, CN;
Zhiyong Zhu, Shanghai, CN;
Gang Yu, Shanghai, CN;
Jiaxiang Zhou, Shanghai, CN;
Shaoling Zhao, Shanghai, CN;
Yukun Sun, Shanghai, CN;
Dengxi Wu, Shanghai, CN;
Aizhen Wu, Shanghai, CN;
Zhiyong Zhu, Shanghai, CN;
Gang Yu, Shanghai, CN;
Jiaxiang Zhou, Shanghai, CN;
Shaoling Zhao, Shanghai, CN;
Shanhai Hua Yi Bio-Tech Lab, , CN;
Abstract
The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the recombinant polypeptides produced by such a method. Using the method of this invention, 1 to 32 copies of GLP-1 (7-36) and/or GLP-1 analog genes may be expressed in tandem and the desired polypeptide can be obtained after cleavage of a fusion protein and further processes of separation and purification thus making possible the production of recombinant polypeptides, including recombinant GLP-1 (7-36) and/or GLP-1 analogs on a large scale, at a significantly reduced production cost.