The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Oct. 23, 2003
Rita T. Bradley, Cary, NC (US);
Scott A. Cook, Garner, NC (US);
Christopher A. Dadd, Holly Springs, NC (US);
Jonathan D. Kent, Holly Springs, NC (US);
Marina N. Korneyeva, Raleigh, NC (US);
Valery V. Novokhatny, Raleigh, NC (US);
James F. Rebbeor, Garner, NC (US);
Christopher J. Stenland, Cary, NC (US);
Jonathan S. Strauss, Walnut Creek, NC (US);
Jarrett C. Terry, Raleigh, NC (US);
Jeffrey A. Yuziuk, Garner, NC (US);
Rita T. Bradley, Cary, NC (US);
Scott A. Cook, Garner, NC (US);
Christopher A. Dadd, Holly Springs, NC (US);
Jonathan D. Kent, Holly Springs, NC (US);
Marina N. Korneyeva, Raleigh, NC (US);
Valery V. Novokhatny, Raleigh, NC (US);
James F. Rebbeor, Garner, NC (US);
Christopher J. Stenland, Cary, NC (US);
Jonathan S. Strauss, Walnut Creek, NC (US);
Jarrett C. Terry, Raleigh, NC (US);
Jeffrey A. Yuziuk, Garner, NC (US);
Talecris Biotherapeutics, Inc., Research Triangle Park, NC (US);
Abstract
Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.