The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Jul. 01, 2004
David A. Sinclair, Chestnut Hill, MA (US);
Konrad T. Howitz, Allentown, PA (US);
Robert E. Zipkin, Wynnewood, PA (US);
Kevin J. Bitterman, Boston, MA (US);
Dudley W. Lamming, Somerville, MA (US);
David A. Sinclair, Chestnut Hill, MA (US);
Konrad T. Howitz, Allentown, PA (US);
Robert E. Zipkin, Wynnewood, PA (US);
Kevin J. Bitterman, Boston, MA (US);
Dudley W. Lamming, Somerville, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Biomol International LP, Plymouth Meeting, PA (US);
Abstract
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.