The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Mar. 03, 2006
Applicants:
José Galindro, Lisbon, PT;
Susana Marto, Costa da Caparica, PT;
João Bandarra, Loures, PT;
William Heggie, Palmela, PT;
Inventors:
José Galindro, Lisbon, PT;
Susana Marto, Costa da Caparica, PT;
João Bandarra, Loures, PT;
William Heggie, Palmela, PT;
Assignee:
Hovione Inter Ltd., Lucerne, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 233/65 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for the production of iohexol comprises alkylating 5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide using 2(2-methoxy-ethoxy)-ethanol as solvent in the presence of a base, and optionally isolating crude iohexol from the reaction mixture. Preferably, the alkylating agent is 1-chloro-2,3 propanediol and the base is an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.