The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Oct. 31, 2005
Xuhong Qian, Shanghai, CN;
Yonggang LI, Shanghai, CN;
Yufang Xu, Shanghai, CN;
Jian Ding, Shanghai, CN;
Liping Lin, Shanghai, CN;
Zehong Miao, Shanghai, CN;
Hong Zhu, Shanghai, CN;
Baoyuan Qu, Shanghai, CN;
Xuhong Qian, Shanghai, CN;
Yonggang Li, Shanghai, CN;
Yufang Xu, Shanghai, CN;
Jian Ding, Shanghai, CN;
Liping Lin, Shanghai, CN;
Zehong Miao, Shanghai, CN;
Hong Zhu, Shanghai, CN;
Baoyuan Qu, Shanghai, CN;
East China University of Science and Technology, Shanghai, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, CN;
Dalian University of Technology, Dalian, CN;
Abstract
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.