The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Jun. 10, 2003
Robert Ramage, Lothian, GB;
Robin Plevin, Strathclyde, GB;
Kevin Thomas Shaw, Lothian, GB;
LU Jiang, Dallan, CN;
Louise Claire Young, Strathclyde, GB;
Alan Lang Harvey, Strathclyde, GB;
Pu Wang, Edinburgh, GB;
Toru Kanke, Musashino, JP;
Junichi Kawagoe, Kawagoe, JP;
Mototsugu Kabeya, Higashimurayama, JP;
Robert Ramage, Lothian, GB;
Robin Plevin, Strathclyde, GB;
Kevin Thomas Shaw, Lothian, GB;
Lu Jiang, Dallan, CN;
Louise Claire Young, Strathclyde, GB;
Alan Lang Harvey, Strathclyde, GB;
Pu Wang, Edinburgh, GB;
Toru Kanke, Musashino, JP;
Junichi Kawagoe, Kawagoe, JP;
Mototsugu Kabeya, Higashimurayama, JP;
The University of Edinburgh, Lothian, GB;
The University of Strathclyde, Strathclyde, GB;
Kowa Company, Ltd., Aichi, JP;
Abstract
The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH)—CO—NH-Leu-Ile-Gly-AA-AA-CO—R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA-AArepresents Lys-Val or Arg-Leu; and R represents —OH or —NH, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof. The peptide derivative is useful as a prophylactic and therapeutic agent of dysfunction of masticatory, dysphagia, dysgeusia, ozostomia, intra-oral cavity dysphoria, intra-oral cavity infections, intra-oral cavity inflammations, dry eye, ectocornea detachment, keratitis, corneal ulcer, conjunctivitis, stomach ulcer, duodenal ulcer, gastritis, diarrhea, enteritis or Sjogren's syndrome.