The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Jun. 27, 2003
Joel Moss, Bethesda, MD (US);
Linda Stevens, Gaithersburg, MD (US);
Christelle Bourgeois, Bethesda, MD (US);
Rita Bortell, Shirley, MA (US);
Joel Moss, Bethesda, MD (US);
Linda Stevens, Gaithersburg, MD (US);
Christelle Bourgeois, Bethesda, MD (US);
Rita Bortell, Shirley, MA (US);
The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);
University of Massachusetts, Boston, MA (US);
Abstract
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.