The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Jan. 21, 2004
Craig Duane Dickinson, San Diego, CA (US);
Alain Philippe Vasserot, Carlsbad, CA (US);
Jeffry Dean Watkins, Encinitas, CA (US);
Jirong LU, Indianapolis, IN (US);
Craig Duane Dickinson, San Diego, CA (US);
Alain Philippe Vasserot, Carlsbad, CA (US);
Jeffry Dean Watkins, Encinitas, CA (US);
Jirong Lu, Indianapolis, IN (US);
Applied Molecular Evolution, Inc., San Diego, CA (US);
Abstract
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.