The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2009
Filed:
Mar. 03, 2003
James L. Leighton, New York, NY (US);
Xiaolun Wang, New York, NY (US);
James Kinnaird, Kent, GB;
The Trustees of Columbia University In the City of New York, New York, NY (US);
Abstract
A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting a reagent of the formula (II) with an aldehyde of the formula RCHO to form the alcohol. Xis one of O and C(R)(R). Each of Xand Xis independently O or N—R. Each of Cand Cis independently an achiral center, an (S) chiral center or an (R) chiral center. Rand Rare (i) each independently Calkyl, Caryl or Cheteroaryl, or (ii) taken together to form a C—Calkylene chain which together with Cand Cforms a 5-membered or 6-membered aliphatic ring. Rand Rare each independently hydrogen, Calkyl, Caryl or Cheteroaryl. R is Calkyl, Caryl or Cheteroaryl. Each of R, R, R, R, Ris independently hydrogen, C—Calkyl, Caryl, Cheteroaryl, Calkoxy, Caryloxy, Cdialkylamino, Calkyl-Carylamino, Cdiarylamino, or halogen. Ris halogen, hydrogen, Calkyl, Caryl, Cheteroaryl, Calkoxy, Caryloxy, Calkyl-Carylamino, Cdiarylamino, OSOCFor SR. Rmay be Calkyl, Caryl, or Cheteroaryl.