The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2009
Filed:
Feb. 13, 2009
Nicholas J. Papadopoulos, LaGrangeville, NY (US);
Joel H. Martin, Putnam Valley, NY (US);
Eric Smith, New York, NY (US);
Irene Noguera-troise, Bay Shore, NY (US);
Gavin Thurston, White Plains, NY (US);
Nicholas J. Papadopoulos, LaGrangeville, NY (US);
Joel H. Martin, Putnam Valley, NY (US);
Eric Smith, New York, NY (US);
Irene Noguera-Troise, Bay Shore, NY (US);
Gavin Thurston, White Plains, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds dimeric hDII4 with an affinity of 75 pM or better, as measured by surface plasmon resonance.