The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2009
Filed:
Aug. 21, 2003
Samuel I. Stupp, Chicago, IL (US);
Erik D. Spoerke, Evanston, IL (US);
Shawn G. Anthony, New Stanton, PA (US);
Krista L. Niece, Evanston, IL (US);
Samuel I. Stupp, Chicago, IL (US);
Erik D. Spoerke, Evanston, IL (US);
Shawn G. Anthony, New Stanton, PA (US);
Krista L. Niece, Evanston, IL (US);
North Western University, Evanston, IL (US);
Abstract
The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.