The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2009
Filed:
Jun. 12, 2003
Nicholas A. Kotov, Stillwater, OK (US);
Shaopeng Wang, Stillwater, OK (US);
Nicholas A. Kotov, Stillwater, OK (US);
Shaopeng Wang, Stillwater, OK (US);
The Board of Regents for Oklahoma State University, Stillwater, OK (US);
Abstract
A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and inverted colloidal crystals are used to form an ordered structure for use as a scaffold for tissue engineering. The porosity of the cell growth matrix may be modified by the selection of particles of appropriate diameter. Further, the surface of colloidal crystals can be easily modified to accommodate many organic species including biomolecules. Layer-by-layer materials are used for tissue engineering to control cell development by using sequential layering of bioactive species wherein the number and order of LBL layers deposited between layers containing a particular protein are controlled. LBL may also be used for timed release of bioactive species. Increased control differentiation factors release and control of cell attachments to the scaffold are achieved to better mimic natural tissue development.