The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2009
Filed:
Apr. 21, 2008
Applicants:
Jiing-kuan Yee, Arcadia, CA (US);
Gilles H Michel, Galveston, FR;
Inventors:
Jiing-Kuan Yee, Arcadia, CA (US);
Gilles H Michel, Galveston, FR;
Assignee:
City of Hope, Duarte, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/33 (2006.01); C12N 15/49 (2006.01); C12N 15/52 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner.