The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2009
Filed:
May. 09, 2006
Alan M. Fogelman, Beverly Hills, CA (US);
Gattadahalli M. Anantharamaiah, Birmingham, AL (US);
Mohamad Navab, Los Angeles, CA (US);
Alan M. Fogelman, Beverly Hills, CA (US);
Gattadahalli M. Anantharamaiah, Birmingham, AL (US);
Mohamad Navab, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptides comprise an 18 amino acid class A amphipathic helix with protecting groups on the amino and the carboxyl terminus. The peptides are highly stable, readily administered via an oral route, and effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles, and/or to promote lipid transport and detoxification. When administered with a statin, the peptides enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose.