The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
Dec. 26, 2002
Jaeheon Lee, Yongin-si, KR;
Taehee Ha, Suwon-si, KR;
Chulhyun Park, Seongnam-si, KR;
Hoechul Lee, Yongin-si, KR;
Gwansun Lee, Seoul, KR;
Youngkil Chang, Seoul, KR;
Jaeheon Lee, Yongin-si, KR;
Taehee Ha, Suwon-si, KR;
Chulhyun Park, Seongnam-si, KR;
Hoechul Lee, Yongin-si, KR;
Gwansun Lee, Seoul, KR;
Youngkil Chang, Seoul, KR;
Hanmi Pharm., Co., Ltd., , KR;
Abstract
Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin.