The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
Oct. 05, 2005
Avraham Cohen, Tel Aviv, IL;
Suzy Charbit, Créteil, FR;
François Schutze, Saint-Nom-la-Bretèche, FR;
Frédéric Martinet, Paris, FR;
Patricia Gizecki, Poitiers, FR;
Avraham Cohen, Tel Aviv, IL;
Suzy Charbit, Créteil, FR;
François Schutze, Saint-Nom-la-Bretèche, FR;
Frédéric Martinet, Paris, FR;
Patricia Gizecki, Poitiers, FR;
Sidem Pharma SA, Luxembourg, LU;
Abstract
The present invention concerns enantioselective preparation of sulphoxide derivatives or their salts. The method consist in performing an enantioselective oxidation of a sulphur of general formula (I) A —CH—SB, wherein: A is a diversely substituted pyridinyl ring and B is a heterocyclic radical comprising an imidazo-pyridinyl ring, using an oxidizing agent in the presence of a titanium-based catalyst and a chiral ligand consisting of a cyclic beta or gamma-amino-alcohol, in an organic solvent, followed, if required, by salt formation with a base. The invention is useful for preparing sulphoxides useful in therapeutics.