The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
May. 16, 2003
Sui Xiong Cai, San Diego, CA (US);
Songchun Jiang, San Diego, CA (US);
William E. Kemnitzer, San Diego, CA (US);
Hong Zhang, San Diego, CA (US);
Giorgio Attardo, Laval, CA;
Real Denis, Montreal, CA;
Sui Xiong Cai, San Diego, CA (US);
Songchun Jiang, San Diego, CA (US);
William E. Kemnitzer, San Diego, CA (US);
Hong Zhang, San Diego, CA (US);
Giorgio Attardo, Laval, CA;
Real Denis, Montreal, CA;
Cytovia, Inc., San Diego, CA (US);
Shire BioChem, Inc., Quebec, CA;
Abstract
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R, R-R, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.