The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
Dec. 19, 2003
David George Allen, Stevenage, GB;
Diane Mary Coe, Stevenage, GB;
Caroline Mary Cook, Stevenage, GB;
Anthony William James Cooper, Stevenage, GB;
Michael Dennis Dowle, Stevenage, GB;
Christopher David Edlin, Stevenage, GB;
Julie Nicole Hamblin, Stevenage, GB;
Martin Redpath Johnson, Stevenage, GB;
Paul Spencer Jones, Stevenage, GB;
Mika Kristian Lindvall, Emeryville, CA (US);
Charlotte Jane Mitchell, Stevenage, GB;
Alison Judith Redgrave, Stevenage, GB;
David George Allen, Stevenage, GB;
Diane Mary Coe, Stevenage, GB;
Caroline Mary Cook, Stevenage, GB;
Anthony William James Cooper, Stevenage, GB;
Michael Dennis Dowle, Stevenage, GB;
Christopher David Edlin, Stevenage, GB;
Julie Nicole Hamblin, Stevenage, GB;
Martin Redpath Johnson, Stevenage, GB;
Paul Spencer Jones, Stevenage, GB;
Mika Kristian Lindvall, Emeryville, CA (US);
Charlotte Jane Mitchell, Stevenage, GB;
Alison Judith Redgrave, Stevenage, GB;
Glaxo Group Limited, Greenford, Middlesex, GB;
Abstract
The invention relates to a compound of formula (I) or a salt thereof: wherein: Ris Calkyl, Cfluoroalkyl or —(CH)OH; Ris a hydrogen atom (H), methyl or Cfluoroalkyl; Ris a hydrogen atom (H) or Calkyl; Ris optionally substituted branched Calkyl, optionally substituted Ccycloalkyl, optionally substituted mono-unsaturated-Ccycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which nand nindependently are 1 or 2; and Y is O, S, SO, or NR; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.