The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
Jan. 05, 2007
Paul L. Feldman, Research Triangle Park, NC (US);
David Kendall Jung, Research Triangle Park, NC (US);
Istvan Kaldor, Research Triangle Park, NC (US);
Gregory J. Pacofsky, Research Triangle Park, NC (US);
Jeffrey A. Stafford, Research Triangle Park, NC (US);
Jeffrey H. Tidwell, Research Triangle Park, NC (US);
Paul L. Feldman, Research Triangle Park, NC (US);
David Kendall Jung, Research Triangle Park, NC (US);
Istvan Kaldor, Research Triangle Park, NC (US);
Gregory J. Pacofsky, Research Triangle Park, NC (US);
Jeffrey A. Stafford, Research Triangle Park, NC (US);
Jeffrey H. Tidwell, Research Triangle Park, NC (US);
CeNes Limited, Cambridge, GB;
Abstract
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.