The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2009
Filed:
Dec. 05, 2003
Jui H. Wang, Williamsville, NY (US);
Long Shen, Tonawanda, NY (US);
Xiaolan Chen, North Tonawanda, NY (US);
Jui H. Wang, Williamsville, NY (US);
Long Shen, Tonawanda, NY (US);
Xiaolan Chen, North Tonawanda, NY (US);
The Research Foundation of State University of New York, Amherst, NY (US);
Abstract
The present invention discloses antisense poly-2'-O-(2,4-dinitrophenyl) oligoribonucleotides which are capable of down regulating the expression of the RIsubunit of protein kinase A. An example is 5′-GGCUGCGUGCCUCCUCACUGG (named antisense poly-DNP RNA-21) or a sequence which has a one-base mismatch therewith. The antisense oligoribonucleotide can be synthesized by in vitro transcription followed by chemical derivatization. The base sequence of the oligoribonucleotides is complementary to that of nt 110 to 130 in RI/PKA mRNA. The antisense poly-DNP RNA-21 was found to inhibit cell growth with ICvalues in the nanomolar range. These oligonucleotides can be used as effective anti-cancer agents.