The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 05, 2009

Filed:

Jul. 25, 2003
Applicants:

Herman Jan Pel, Almere, NL;

Sylvia Hopper, München, DE;

Inventors:

Herman Jan Pel, Almere, NL;

Sylvia Hopper, München, DE;

Assignee:

DSM IP Assets B.V., Heerlen, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12Q 1/58 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Four new genes, and the enzymes that they encode, are disclosed, which are present inand which are involved in at least five steps in the biosynthetic pathway of vitamin B. The four enzymes are: A: cobyrinic acid a, c-diamide synthase; B: a bifunctional enzyme, which is a cobinamide kinase and a cobinamide phosphate guanyl transferase; C: a cobalamin 5-phosphate synthase; and D: an adenosyl transferase. Genes encoding the four enzymes can be placed inshuttle vectors and used to transformhosts, in order to improve the production of vitamin Bor a precursor thereof on an industrial scale during fermentation.


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