The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2009
Filed:
Jul. 09, 2007
Carmen Cuevas, Madrid, ES;
Marta Perez, Madrid, ES;
Andres Francesch, Madrid, ES;
Carolina Fernandez, Madrid, ES;
Jose Luis Chicharro, Madrid, ES;
Pilar Gallego, Madrid, ES;
Maria Zarzuelo, Madrid, ES;
Fernando DE Calle, Madrid, ES;
Ignacio Manzanares, Madrid, ES;
Carmen Cuevas, Madrid, ES;
Marta Perez, Madrid, ES;
Andres Francesch, Madrid, ES;
Carolina Fernandez, Madrid, ES;
Jose Luis Chicharro, Madrid, ES;
Pilar Gallego, Madrid, ES;
Maria Zarzuelo, Madrid, ES;
Fernando de Calle, Madrid, ES;
Ignacio Manzanares, Madrid, ES;
Pharma Mar, S.A., Madrid, ES;
Abstract
Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; Ris an amidomethylene group or an acyloxymethylene group; Rand Rare independently chosen from —H, —OH or —OCOCHOH, or Rand Rare both keto and the ring A is a p-benzoquinone ring; Rand Rare both —H ozone is —H and the other is —OH, —OCHor —OCHCH, or Rand Rtogether form a keto group; and Rand Rare independently chosen from —H or —OH, or Rand Rare both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.