The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2009
Filed:
Oct. 05, 2005
Jin-jun Liu, Warren, NJ (US);
Kin-chun Luk, North Caldwell, NJ (US);
Giacomo Pizzolato, Glen Ridge, NJ (US);
Yi Ren, Warren, NJ (US);
Kshitij Chhabilbhai Thakkar, Clifton, NJ (US);
Peter Michael Wovkulich, Nutley, NJ (US);
Zhuming Zhang, Hillsborough, NJ (US);
Jin-Jun Liu, Warren, NJ (US);
Kin-Chun Luk, North Caldwell, NJ (US);
Giacomo Pizzolato, Glen Ridge, NJ (US);
Yi Ren, Warren, NJ (US);
Kshitij Chhabilbhai Thakkar, Clifton, NJ (US);
Peter Michael Wovkulich, Nutley, NJ (US);
Zhuming Zhang, Hillsborough, NJ (US);
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention provides compounds of formula I wherein R, R, R, R, and Rare described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.