The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 28, 2009

Filed:

Mar. 01, 2006
Applicants:

John J. Venit, North Brunswick, NJ (US);

Mandar V. Dali, Bridgewater, NJ (US);

Manisha M. Dali, Bridgewater, NJ (US);

Yande Huang, Belle Mead, NJ (US);

Charles E. Dahlheim, Lawrenceville, NJ (US);

Ravindra W. Tejwani, Somerset, NJ (US);

Inventors:

John J. Venit, North Brunswick, NJ (US);

Mandar V. Dali, Bridgewater, NJ (US);

Manisha M. Dali, Bridgewater, NJ (US);

Yande Huang, Belle Mead, NJ (US);

Charles E. Dahlheim, Lawrenceville, NJ (US);

Ravindra W. Tejwani, Somerset, NJ (US);

Assignee:

Bristol-Myers Squibb Co., Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/66 (2006.01); C07F 9/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.


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