The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2009
Filed:
May. 10, 2002
Timothy E. Benson, Kalamazoo, MI (US);
D. Danielle Woods, Kalamazoo, MI (US);
Donald Bryan Prince, Parchment, MI (US);
Timothy E. Benson, Kalamazoo, MI (US);
D. Danielle Woods, Kalamazoo, MI (US);
Donald Bryan Prince, Parchment, MI (US);
Elan Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and c, wherein a is about 53 Å to about 103 Å, b is about 85 Å to about 125 Å, c is about 40 Å to about 60 Å, and α=γ=90°, and β is about 85° to about 105°, and in a preferred example, comprising unit cell dimensions as follows: a is 73.1 Å, b is 105.1 Å, c is 50.5 Å, and α=γ=90°, and β is 94.8, wherein the Matthews coefficient of said crystal is 2.1 Å/Da with 42% solvent, and wherein said crystal diffracts to 1.7 Å resolution.