The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2009
Filed:
Feb. 08, 2005
Volker Doring, Paris, FR;
Leslie A. Nangle, San Diego, CA (US);
Tamara L. Hendrickson, Baltimore, MD (US);
Valerie DE Crecy-lagard, La Jolla, CA (US);
Paul Schimmel, La Jolla, CA (US);
Philippe Marliere, Etiolles, FR;
Volker Doring, Paris, FR;
Leslie A. Nangle, San Diego, CA (US);
Tamara L. Hendrickson, Baltimore, MD (US);
Valerie De Crecy-Lagard, La Jolla, CA (US);
Paul Schimmel, La Jolla, CA (US);
Philippe Marliere, Etiolles, FR;
Institut Pasteur, Paris, FR;
The Scripps Research Institute, La Jolla, CA (US);
Evologic GmbH, Cologne, DE;
Abstract
The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.