The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Apr. 06, 2006
Tracy Doucette, Stanhope, CA;
Henriette Husum Bak-jensen, Copenhagen S, DK;
Melissa Perry, Charlottetown, CA;
Catherine Ryan, Charlottetown, CA;
R. Andrew Tasker, Charlottetown, CA;
Tracy Doucette, Stanhope, CA;
Henriette Husum Bak-Jensen, Copenhagen S, DK;
Melissa Perry, Charlottetown, CA;
Catherine Ryan, Charlottetown, CA;
R. Andrew Tasker, Charlottetown, CA;
University of Prince Edward Island, Charlottetown, PE, CA;
H:S Rigshospitalet, Copenhagen, DK;
Abstract
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.