The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Feb. 18, 2008
Muhammed Majeed, Piscataway, NJ (US);
Rajinder Kumar Bammi, Bangalore, IN;
Natarajan Sankaran, Bangalore, IN;
Subbalakshmi Prakash, Piscataway, NJ (US);
Kalyanam Nagabhushanam, Piscataway, NJ (US);
Samuel Manoharan Thomas, Bangalore, IN;
Susmitha Anand, Bangalore, IN;
Geetha Kanhangad-gangadharan, Bangalore, IN;
Muhammed Majeed, Piscataway, NJ (US);
Rajinder Kumar Bammi, Bangalore, IN;
Natarajan Sankaran, Bangalore, IN;
Subbalakshmi Prakash, Piscataway, NJ (US);
Kalyanam Nagabhushanam, Piscataway, NJ (US);
Samuel Manoharan Thomas, Bangalore, IN;
Susmitha Anand, Bangalore, IN;
Geetha Kanhangad-Gangadharan, Bangalore, IN;
Sami Labs Ltd., Bangalore, IN;
Abstract
Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.