The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Feb. 23, 2005
Jinbo Lee, Acton, MA (US);
Zhao-kui Wan, Arlington, MA (US);
Douglas P. Wilson, Ayer, MA (US);
Bruce C. Follows, Littleton, MA (US);
Steven J. Kirincich, Concord, MA (US);
Michael J. Smith, Poland, OH (US);
Jun-jun Wu, Arlington, MA (US);
Kenneth W. Foreman, Syosset, NY (US);
David V. Erbe, Boston, MA (US);
Yan-ling Zhang, Lexington, MA (US);
Weixin Xu, Acton, MA (US);
Steve Y. Tam, Wellesley, MA (US);
Jinbo Lee, Acton, MA (US);
Zhao-Kui Wan, Arlington, MA (US);
Douglas P. Wilson, Ayer, MA (US);
Bruce C. Follows, Littleton, MA (US);
Steven J. Kirincich, Concord, MA (US);
Michael J. Smith, Poland, OH (US);
Jun-Jun Wu, Arlington, MA (US);
Kenneth W. Foreman, Syosset, NY (US);
David V. Erbe, Boston, MA (US);
Yan-Ling Zhang, Lexington, MA (US);
Weixin Xu, Acton, MA (US);
Steve Y. Tam, Wellesley, MA (US);
Wyeth, Madison, NJ (US);
Abstract
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.