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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7521242 B1

PDFFull Text
Date of Patent:
Apr. 21, 2009

Filed:

May. 07, 2004

Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids

Applicants:

Donald L. Court, Frederick, MD (US);

Xin-tian LI, Bejing, CN;

Jian-dong Huang, Hong Kong SAR, CN;

Nina Costantino, Frederick, MD (US);

Depei Liu, Beijing, CN;

Inventors:

Donald L. Court, Frederick, MD (US);

Xin-tian Li, Bejing, CN;

Jian-Dong Huang, Hong Kong SAR, CN;

Nina Costantino, Frederick, MD (US);

Depei Liu, Beijing, CN;

Assignee:

The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);

Attorney:

Klarquist Sparkman, LLP

Primary Examiner:

Nancy Vogel

Int. Cl.
CPC ...
C12N 15/87 (2006.01); C12N 15/90 (2006.01); C12N 1/21 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule has a sufficient number of nucleotides homologous to the target nucleic acid to enable homologous recombination with the target nucleic acid. The host cell includes a de-repressible promoter operably linked to a nucleic acid encoding a single-stranded binding protein and is deficient for mismatch repair. Isolated host cells of use in this method are also disclosed.

Find Patent Forward Citations

Court, Donald. (2009). Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids (U.S. Patent No. 7521242). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7521242

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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