The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Oct. 18, 2007
Maria G. Pau, Leiden, NL;
Lennart Holterman, Zoetermeer, NL;
Jorn Kaspers, Leiden, NL;
Antonius J. H. Stegmann, Katwijk, NL;
Maria G. Pau, Leiden, NL;
Lennart Holterman, Zoetermeer, NL;
Jorn Kaspers, Leiden, NL;
Antonius J. H. Stegmann, Katwijk, NL;
Crucell Holland B.V., Leiden, NL;
Abstract
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against differentinfections, such as infections byor. Novel codon-optimized circumsporozoite genes are disclosed. Preferably, replication-defective adenoviruses are used, derived from serotypes that encounter low titers of neutralizing antibodies. The invention, therefore, also relates to the use of different adenoviral serotypes that are administered to elicit a strong immune response, either in single vaccination set-ups or in prime-boost set-ups in which compositions based on different serotypes can be applied.