The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Oct. 03, 2001
X. Charlene Liao, Palo Alto, CA (US);
Esteban Masuda, Menlo Park, CA (US);
Peter Chu, San Francisco, CA (US);
Jorge Pardo, San Francisco, CA (US);
Congfen LI, Davis, CA (US);
Haoran Zhao, Foster City, CA (US);
Ying-ping Jiang, Lafayette, CA (US);
Collin Spencer, San Francisco, CA (US);
X. Charlene Liao, Palo Alto, CA (US);
Esteban Masuda, Menlo Park, CA (US);
Peter Chu, San Francisco, CA (US);
Jorge Pardo, San Francisco, CA (US);
Congfen Li, Davis, CA (US);
Haoran Zhao, Foster City, CA (US);
Ying-Ping Jiang, Lafayette, CA (US);
Collin Spencer, San Francisco, CA (US);
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.