The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2009
Filed:
Aug. 28, 2006
Brian Gliniak, Seattle, WA (US);
Xiao-dong Yang, Palo Alto, CA (US);
Sharon Wong-madden, Bellevue, WA (US);
Ian Foltz, Burnaby, CA;
Xiao Feng, The Woodlands, TX (US);
Alison Fitch, Vancouver, CA;
Stephen Foster, Newbury Park, CA (US);
Randal R. Ketchem, Snohomish, WA (US);
Brian Gliniak, Seattle, WA (US);
Xiao-Dong Yang, Palo Alto, CA (US);
Sharon Wong-Madden, Bellevue, WA (US);
Ian Foltz, Burnaby, CA;
Xiao Feng, The Woodlands, TX (US);
Alison Fitch, Vancouver, CA;
Stephen Foster, Newbury Park, CA (US);
Randal R. Ketchem, Snohomish, WA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ('TRAIL') Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.