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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7517994 B1

PDFFull Text
Date of Patent:
Apr. 14, 2009

Filed:

May. 18, 2005

Heterocyclic inhibitors of mek and methods of use thereof

Applicants:

Allison L. Marlow, Louisville, CO (US);

Eli Wallace, Lyons, CO (US);

Jeongbeob Seo, Broomfield, CO (US);

Joseph P. Lyssikatos, Superior, CO (US);

Hong Woon Yang, Superior, CO (US);

James Blake, Longmont, CO (US);

Inventors:

Allison L. Marlow, Louisville, CO (US);

Eli Wallace, Lyons, CO (US);

Jeongbeob Seo, Broomfield, CO (US);

Joseph P. Lyssikatos, Superior, CO (US);

Hong Woon Yang, Superior, CO (US);

James Blake, Longmont, CO (US);

Assignee:

Array Biopharma Inc., Boulder, CO (US);

Attorney:

Hogan & Hartson LLP

Primary Examiner:

Mark L Berch

Assistant Examiner:

Cecilia M Jaisle

Int. Cl.
CPC ...
C07D 211/76 (2006.01); C07D 211/86 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 237/04 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 237/12 (2006.01); C07D 487/06 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01); C07D 409/06 (2006.01); C07D 411/06 (2006.01); C07D 419/06 (2006.01); C07D 221/04 (2006.01); C07D 213/22 (2006.01); C07D 213/26 (2006.01); A61K 31/501 (2006.01); A61K 31/4412 (2006.01); A61P 35/00 (2006.01); C07D 417/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, Rand R, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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