The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2009
Filed:
Nov. 07, 2003
Nobuhiro Ito, Kawagoe, JP;
Tsuneaki Maesawa, Kawagoe, JP;
Kazushige Muto, Kawagoe, JP;
Kosaku Hirota, Gifu, JP;
Hironao Sajiki, Gifu, JP;
Nobuhiro Ito, Kawagoe, JP;
Tsuneaki Maesawa, Kawagoe, JP;
Kazushige Muto, Kawagoe, JP;
Kosaku Hirota, Gifu, JP;
Hironao Sajiki, Gifu, JP;
Wako Pure Chemical Industries, Ltd., Osaka-shi, Osaka, JP;
Abstract
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.