The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2009
Filed:
Nov. 09, 2006
Raymond Stanley Norton, Ivanhoe, AU;
Jeffrey James Babon, North Carlton, AU;
Sandra Elaine Nicholson, Williamstown, AU;
Nicos Anthony Nicola, Mont Albert, AU;
Edward James Mcmanus, Clifton Hill, AU;
Manuel Baca, Viewbank, AU;
Shenggen Yao, Doncaster, AU;
Raymond Stanley Norton, Ivanhoe, AU;
Jeffrey James Babon, North Carlton, AU;
Sandra Elaine Nicholson, Williamstown, AU;
Nicos Anthony Nicola, Mont Albert, AU;
Edward James McManus, Clifton Hill, AU;
Manuel Baca, Viewbank, AU;
Shenggen Yao, Doncaster, AU;
Walter and Eliza Hall Institute of Medical Research, Parkville, AU;
Abstract
The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.