The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2009
Filed:
Sep. 29, 2004
Daniel B. Rifkin, New York, NY (US);
John S. Munger, New York, NY (US);
Justin P. Annes, New York, NY (US);
Daniel B. Rifkin, New York, NY (US);
John S. Munger, New York, NY (US);
Justin P. Annes, New York, NY (US);
New York University, New York, NY (US);
Abstract
A method of screening for a protein involved in the extracellular regulation of latent TGFβ activation by transducing a cell line with a retroviral cDNA library to create a reporter cell line that produces green fluorescent protein (GFP) in response to TGF-β signaling; growing individual clones created by the reporter cell line; co-culturing each individual clone with a second TGF-β reporter cell line that produces luciferase in response to TGF-β, wherein the luciferase production identifies positive clones; and identifying a mechanism of latent TGF-β activation that is employed by the positive clones. A TGFβ reporter cell line including a cell line; and a retroviral cDNA library, wherein the reporter cell line produces GFP in response to TGF-β signaling. A method of screening for gene products involved in a biological process.