The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2009
Filed:
Sep. 10, 2003
John S. Wai, Harleysville, PA (US);
Boyoung Kim, Lansdale, PA (US);
Thorsten E. Fisher, Hatfield, PA (US);
Peter D. Williams, Harleysville, PA (US);
H. Marie Langford, Lansdale, PA (US);
John S. Wai, Harleysville, PA (US);
Boyoung Kim, Lansdale, PA (US);
Thorsten E. Fisher, Hatfield, PA (US);
Peter D. Williams, Harleysville, PA (US);
H. Marie Langford, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.