The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2009
Filed:
Oct. 29, 2002
Eddy Jean Edgard Freyne, Rumst, BE;
Peter Jacobus Johannes Antonius Buijnsters, Breda, NL;
Marc Willems, Vosselaar, BE;
Werner Constant Johan Embrechts, Beerse, BE;
Christopher John Love, Deurne, BE;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Paulus Joannes Lewi, Turnhout, BE;
Jan Heeres, Vosselaar, BE;
Marc René DE Jonge, Tilburg, NL;
Lucien Maria Henricus Koymans, Retie, BE;
Hendrik Maarten Vinkers, Antwerp, BE;
Koen Jeanne Alfons Van Aken, Kortrijk, BE;
Gaston Stanislas Marcella Diels, Ravels, BE;
Eddy Jean Edgard Freyne, Rumst, BE;
Peter Jacobus Johannes Antonius Buijnsters, Breda, NL;
Marc Willems, Vosselaar, BE;
Werner Constant Johan Embrechts, Beerse, BE;
Christopher John Love, Deurne, BE;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Paulus Joannes Lewi, Turnhout, BE;
Jan Heeres, Vosselaar, BE;
Marc René de Jonge, Tilburg, NL;
Lucien Maria Henricus Koymans, Retie, BE;
Hendrik Maarten Vinkers, Antwerp, BE;
Koen Jeanne Alfons Van Aken, Kortrijk, BE;
Gaston Stanislas Marcella Diels, Ravels, BE;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted CalkyloxyCalkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhaloCalkyloxy; polyhaloCalkylthio; R; R—Calkyl; R—O—; R—S—; R—C(═O)—; R—S(═O)—; R—S(═O)—; R—S(═O)—NH—; R—S(═O)—NH—; R—C(═O)—; —NHC(═O)H; —C(═O)NHNH; R—C(═O)—NH—; R—C(═O)—NH—; —C(═NH)R—C(═NH)R; Ris an optionally substituted heterocycle provided that —X—Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.