The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2009
Filed:
Mar. 05, 2007
Samuel I. Achilefu, St. Louis, MO (US);
Raghavan Rajagopalan, Solon, OH (US);
Richard B. Dorshow, St. Louis, MO (US);
Joseph E. Bugaj, St. Charles, MO (US);
Muthunadar P. Periasamy, Chesterfield, MO (US);
Samuel I. Achilefu, St. Louis, MO (US);
Raghavan Rajagopalan, Solon, OH (US);
Richard B. Dorshow, St. Louis, MO (US);
Joseph E. Bugaj, St. Charles, MO (US);
Muthunadar P. Periasamy, Chesterfield, MO (US);
Mallinckrodt Inc., Hazelwood, MO (US);
Abstract
Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.