The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2009
Filed:
Jun. 02, 2005
Ashis Kumar Saha, Harleysville, PA (US);
David William End, Ambler, PA (US);
Bart Lieven Daniel DE Corte, Southampton, PA (US);
Henry Joseph Breslin, Lansdale, PA (US);
LI Liu, Doylestown, PA (US);
Ashis Kumar Saha, Harleysville, PA (US);
David William End, Ambler, PA (US);
Bart Lieven Daniel De Corte, Southampton, PA (US);
Henry Joseph Breslin, Lansdale, PA (US);
Li Liu, Doylestown, PA (US);
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
A prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein Land Lare R—Y— wherein each (R—Y)— substituent is defined independently of the other; Y is Calkanediyl, Calkenediyl, Calkynediyl, C(═O), or a direct bond; Ris hydrogen, cyano, aryl or a substituted or unsubstituted Cheterocycle; =Z-Z=Z- represents a radical of formula ═N—N═CH— (a-1), ═N—CH═N— (a-2), ═CH—N═N— (a-3); X is SO, (CH)wherein n is 1 to 4, C(═O), C(═S), or a direct bond; Ris aryl, Ccycloalkyl, Ccycloalkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted Cheterocycle, Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl, hydroxyCalkyl, hydroxyCalkyloxy, hydroxyCalkylthio and arylCalkylthio, Calkyl or Calkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted Cheterocycle, Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl, hydroxyCalkyl, hydroxyCalkyloxy, hydroxyCalkylthio and arylCalkylthio; Ris aryl, —NRR, a substituted or unsubstituted Cheterocycle, or Calkenediyl substituted with a substituted or unsubstituted Cheterocycle or aryl; Ris hydrogen, aryl, Ccycloalkyl, Calkyl or Calkyl substituted with Ccycloalkyl, hydroxycarbonyl, Calkyloxycarbonyl or aryl; Rand Rare each independently selected from hydrogen, a substituted or unsubstituted Cheterocycle, aryl, Calkyl and Calkyl substituted with one or more substituents selected from hydroxy, aryl, aryloxy or a substituted or unsubstituted Cheterocycle.