The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2009
Filed:
Jan. 11, 2006
Eu-gene OH, Taejon, KR;
Sung-bo Ko, Taejon, KR;
Kyung-hwa Kim, Taejon, KR;
In-kyu Chang, Taejon, KR;
Dennis W. Choi, St. Louis, MO (US);
Laura L. Dugan, St. Louis, MO (US);
Jae-young Koh, Seoul, KR;
In-jae Shin, Koyang, KR;
Moo-ho Won, Chuncheon, KR;
Eu-Gene Oh, Taejon, KR;
Sung-Bo Ko, Taejon, KR;
Kyung-Hwa Kim, Taejon, KR;
In-Kyu Chang, Taejon, KR;
Dennis W. Choi, St. Louis, MO (US);
Laura L. Dugan, St. Louis, MO (US);
Jae-Young Koh, Seoul, KR;
In-Jae Shin, Koyang, KR;
Moo-Ho Won, Chuncheon, KR;
Abstract
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.