The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2009
Filed:
Nov. 29, 2002
Yoshikazu Yonemitsu, Fukuoka, JP;
Toshihiro Nakajima, Hyogo, JP;
Kenji Nakamaru, Tokyo, JP;
Masanori Kobayashi, Osaka, JP;
Mamoru Hasegawa, Ibaraki, JP;
Yasuji Ueda, Ibaraki, JP;
Akihiro Iida, Ibaraki, JP;
Hiroyuki Sakakibara, Ibaraki, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Toshihiro Nakajima, Hyogo, JP;
Kenji Nakamaru, Tokyo, JP;
Masanori Kobayashi, Osaka, JP;
Mamoru Hasegawa, Ibaraki, JP;
Yasuji Ueda, Ibaraki, JP;
Akihiro Iida, Ibaraki, JP;
Hiroyuki Sakakibara, Ibaraki, JP;
DNAVEC Research Inc., Ibaraki, JP;
Abstract
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene transfer at a high efficiency into host cells. In particular, it was established that genes can be transferred thereby at a high efficiency into cells into which genes can hardly be transferred by the conventional techniques, for example, blood cells and hematopoietic cells including hematopoietic stem cells, and mucous cells including mucosa epithelial cells. The viral vector of the present invention is highly useful as a vector for gene therapy.