The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2009
Filed:
Dec. 02, 2002
Robert E. W. Hancock, Vancouver, CA;
B. Brett Finlay, Richmond, CA;
Monisha Gough Scott, Vancouver, CA;
Dawn Bowdish, Vancouver, CA;
Carrie Melissa Rosenberger, Vancouver, CA;
Jon-paul Steven Powers, Vancouver, CA;
Robert E. W. Hancock, Vancouver, CA;
B. Brett Finlay, Richmond, CA;
Monisha Gough Scott, Vancouver, CA;
Dawn Bowdish, Vancouver, CA;
Carrie Melissa Rosenberger, Vancouver, CA;
Jon-Paul Steven Powers, Vancouver, CA;
The University of British Columbia, Vancouver, British Columbia, CA;
Abstract
A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.