The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2009

Filed:

Aug. 28, 2006
Applicants:

Wei Han, Yardley, PA (US);

Zilun HU, Jamison, PA (US);

Inventors:

Wei Han, Yardley, PA (US);

Zilun Hu, Jamison, PA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 291/06 (2006.01); A61K 31/519 (2006.01); A61K 31/541 (2006.01); C07D 413/12 (2006.01); A61K 31/5355 (2006.01); A61P 25/06 (2006.01); A61P 9/06 (2006.01); A61P 25/08 (2006.01); A61P 1/04 (2006.01); A61P 11/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated Kchannels, especially inhibitors K1.5 which has been linked to the ultra-rapidly activating delayed rectifier, which have the structure stereoisomers including enantiomers thereof and diastereomers thereof, or a pharmaceutically acceptable salt thereof,wherein wherein R, R, R, R, R, R, R, Rand Rare defined herein. Methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds are also provided.


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