The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2009
Filed:
Jun. 11, 2007
Yan Zhou, Saskatoon, CA;
Yeun-kyung Shin, Seoul, KR;
Lorne A. Babiuk, Edmonton, CA;
Qiang Liu, Saskatoon, CA;
Yan Zhou, Saskatoon, CA;
Yeun-Kyung Shin, Seoul, KR;
Lorne A. Babiuk, Edmonton, CA;
Qiang Liu, Saskatoon, CA;
University of Saskatchewan, Saskatoon, Saskatchewan, CA;
Abstract
Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics system for producing attenuated influenza virus NS1 variants, immunogenic compositions comprising live attenuated influenza virus NS1 variants, methods of stimulating an immune response against influenza virus, methods of interfering with influenza virus replication, and methods of treating and preventing influenza virus infection are described.