The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2009
Filed:
Oct. 25, 2004
Christian Reiter, Karsfeld, DE;
Francois Habersetzer, Illkirch-Graffenstaden, FR;
Anne Fournillier, Lyons, FR;
Christian Trepo, Bron, FR;
Claude Desgranges, Paris, FR;
Genevieve Inchauspe, Lyons, FR;
Christian Reiter, Karsfeld, DE;
Francois Habersetzer, Illkirch-Graffenstaden, FR;
Anne Fournillier, Lyons, FR;
Christian Trepo, Bron, FR;
Claude Desgranges, Paris, FR;
Genevieve Inchauspe, Lyons, FR;
Genmab A/S, Copenhagen-K, DK;
Abstract
Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.