The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2009
Filed:
Jun. 05, 2002
Ljiljana Kojic, Vancouver, CA;
Patricia M. Logan, Vancouver, CA;
Jeffery J. Wheeler, Surrey, CA;
Kymberley L. Sutton, Surrey, CA;
Gabriel Bela Kalmar, Richmond, CA;
Ljiljana Kojic, Vancouver, CA;
Patricia M. Logan, Vancouver, CA;
Jeffery J. Wheeler, Surrey, CA;
Kymberley L. Sutton, Surrey, CA;
Gabriel Bela Kalmar, Richmond, CA;
QLT Inc., Vancouver, British Columbia, CA;
Abstract
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-κB. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.